Editorial: Marching Toward 100% Whole Genome Sequencing
نویسندگان
چکیده
منابع مشابه
Editorial: Marching Toward 100% Whole Genome Sequencing
Genomes are becoming recognized as dynamic molecules which modify their structures, mediated through epigenetic mechanisms, in response to intrinsic and extrinsic stimulants, and directed by cell development in single-cell organisms and mammalian cells, examples including V(D)J recombination during B-cell and T-cell lymphocyte maturation, and subsequent class switch recombination and somatic hy...
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Whole-genome sequencing across multiple samples in a population provides an unprecedented opportunity for comprehensively characterizing the polymorphic variants in the population. Although the 1000 Genomes Project (1KGP) has offered brief insights into the value of population-level sequencing, the low coverage has compromised the ability to confidently detect rare and low-frequency variants. I...
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Next-generation sequencing technology has enabled genome-wide analysis of 5mC nucleotides at single-nucleotide resolution. Previous methods for whole-genome bisulfite sequencing (WGBS) yielded reduced genomic representation due to required DNA shearing, ligation of methylated sequencing adapters, and bisulfite conversion of unmethylated cytidine residues prior to sequencing. One disadvantage of...
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Next-generation sequencing technology has enabled genome-wide analysis of 5mC nucleotides at single-nucleotide resolution. Previous methods for whole-genome bisulfite sequencing (WGBS) yielded reduced genomic representation due to required DNA shearing, ligation of methylated sequencing adapters, and bisulfite conversion of unmethylated cytidine residues prior to sequencing. One disadvantage of...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2016
ISSN: 1664-8021
DOI: 10.3389/fgene.2016.00041